Best big city in the following U.S. regions??

Midwest West East South America I say Midwest: Chicago (duh) East: New York West: San Fran South: MIA America: Chicago It has to be a big city and everyone is entitiled to their opinion. REMEMBER has to be a big city. Please give this question a star

Public Comments

1. Midwest: Chicago East: NY West: San Diego South: New Orleans America: San Diego, "America's Finest City". although SF is a close 2nd .
2. chicago seattle new york michigan rio de janeiro (brazil)
3. Midwest :Omaha South: Atlanta West :Phoenix East : Boston Biggest isn't necessarily best